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CPT 95921–95924: A Billing Guide for Autonomic Nervous System Testing

Understanding CPT codes 95921–95924 for autonomic nervous system testing — what's covered, reimbursement rates, documentation requirements, and common billing mistakes to avoid.

Published September 10, 2026 · Updated November 5, 2026

Understanding CPT 95921–95924

The CPT code range 95921–95924 covers autonomic nervous system function testing. These codes are essential for practices offering VitalScan ANS+ assessments.

Code Breakdown

| Code | Description | |------|-------------| | 95921 | Cardiovascular innervation (heart rate response to deep breathing and/or Valsalva) | | 95922 | Vasomotor adrenergic function (beat-to-beat blood pressure with tilt/standing) | | 95923 | Sudomotor (sweat) function — including quantitative sudomotor axon reflex test (QSART) | | 95924 | Combined parasympathetic and sympathetic adrenergic testing (comprehensive panel) |

Typical Reimbursement

Reimbursement varies by payer and region, but typical ranges are:

  • 95921: $120–$200 per test
  • 95923: $100–$180 per test
  • 95924 (comprehensive): $200–$350 per test

A practice performing 3 tests per day at an average of $200 can generate approximately $12,000/month in new revenue.

Documentation Requirements

To ensure clean claims and minimize denials:

  1. Medical necessity: Document the patient's condition that warrants ANS testing (diabetes with neuropathy risk, unexplained syncope, suspected POTS, etc.)
  2. Test results: Include the VitalScan interpretive report in the patient record
  3. Provider signature: The ordering physician must sign off on the test results

Common Billing Mistakes

  • Bundling errors: Don't bill 95921 and 95922 separately if 95924 (comprehensive) was performed — 95924 includes both
  • Missing medical necessity: Claims without documented risk factors are frequently denied
  • Not using the correct diagnosis codes: Use ICD-10 codes that support medical necessity (e.g., E11.42 for diabetic polyneuropathy)

Vascular Testing Codes (93922–93971)

In addition to ANS testing, VitalScan performs vascular studies billable under CPT codes 93922–93971. These cover arterial Doppler, pulse volume recording, and ABI screening — commonly reimbursed at $100–$200 per study.

Key Takeaway

Proper coding and documentation are essential for maximizing reimbursement. The VitalScan system generates reports that support clean claims, and US MedResources provides billing guidance to get your front office up to speed quickly.

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One-Page Reference

CPT 95921–95924 reimbursement summary

Code descriptions, typical reimbursement ranges, ICD-10 pairings, and the CMS bundling note to check before you bill.

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